Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4719200..4719799 Replicon chromosome
Accession NZ_CP099364
Organism Citrobacter braakii strain RHB44-SE-C08

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFL11_RS22945 Protein ID WP_279268317.1
Coordinates 4719488..4719799 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFL11_RS22940 Protein ID WP_131347314.1
Coordinates 4719200..4719487 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL11_RS22925 (4716696) 4716696..4717598 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
NFL11_RS22930 (4717595) 4717595..4718230 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
NFL11_RS22935 (4718227) 4718227..4719156 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
NFL11_RS22940 (4719200) 4719200..4719487 - 288 WP_131347314.1 helix-turn-helix domain-containing protein Antitoxin
NFL11_RS22945 (4719488) 4719488..4719799 - 312 WP_279268317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFL11_RS22950 (4720020) 4720020..4720928 + 909 WP_049041381.1 alpha/beta hydrolase -
NFL11_RS22955 (4720993) 4720993..4721235 + 243 WP_016155179.1 type II toxin-antitoxin system ParD family antitoxin -
NFL11_RS22960 (4721228) 4721228..4721515 + 288 WP_049269420.1 type II toxin-antitoxin system RelE/ParE family toxin -
NFL11_RS22965 (4721521) 4721521..4722462 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
NFL11_RS22970 (4722507) 4722507..4722944 - 438 WP_279268318.1 D-aminoacyl-tRNA deacylase -
NFL11_RS22975 (4722941) 4722941..4723813 - 873 WP_109017836.1 virulence factor BrkB family protein -
NFL11_RS22980 (4723807) 4723807..4724406 - 600 WP_049282314.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12344.51 Da        Isoelectric Point: 10.2893

>T248640 WP_279268317.1 NZ_CP099364:c4719799-4719488 [Citrobacter braakii]
MLFIETEIFTEDVKKLLDDDEYRRLQIFLAIQPDCGDLIQETGGLRKVRWRARGKGKRGGVRIIYFHQIRKSQIRLLLIY
QKGIKDDLTPQEKVLLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10746.39 Da        Isoelectric Point: 11.1842

>AT248640 WP_131347314.1 NZ_CP099364:c4719487-4719200 [Citrobacter braakii]
MDKALFERLTQSMVQMNEIAEGTRQPSRTFHIDAMKIKEIRLSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References