Detailed information of TA system TA248622

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4302948..4303206
• Replicon: chromosome
• Accession: NZ_CP099358
• Organism: Escherichia fergusonii strain RHB02-E1-C03

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: NFJ18_RS20780
• Protein ID: WP_181202950.1
• Coordinates: 4302948..4303100 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4303151..4303206 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NFJ18_RS20750	4298812..4299522	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
NFJ18_RS20755	4299960..4301330	+	1371	WP_000184983.1	MFS transporter	-
NFJ18_RS20760	4301580..4301870	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
NFJ18_RS20765	4302152..4302364	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
NFJ18_RS20770	4302418..4302789	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
NFJ18_RS20775	4302900..4302971	+	72	WP_216665726.1	hypothetical protein	-
NFJ18_RS20780	4302948..4303100	-	153	WP_181202950.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4303151..4303206	+	56	-	-	Antitoxin
NFJ18_RS20785	4303401..4303760	-	360	WP_141095883.1	hypothetical protein	-
NFJ18_RS20790	4303829..4305898	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
NFJ18_RS20795	4305908..4306819	-	912	WP_181202951.1	glycine--tRNA ligase subunit alpha	-
NFJ18_RS20800	4306915..4307214	-	300	WP_024256552.1	YsaB family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5926.17 Da
• Isoelectric Point: 6.9160

>T248622 WP_181202950.1 NZ_CP099358:c4303100-4302948 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT248622 NZ_CP099358:4303151-4303206 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin