Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2208945..2209507 Replicon chromosome
Accession NZ_CP099358
Organism Escherichia fergusonii strain RHB02-E1-C03

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFJ18_RS10860 Protein ID WP_104919749.1
Coordinates 2209229..2209507 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag NFJ18_RS10855 Protein ID WP_000781370.1
Coordinates 2208945..2209229 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ18_RS10840 (2204304) 2204304..2207351 + 3048 WP_015953395.1 formate dehydrogenase-N subunit alpha -
NFJ18_RS10845 (2207364) 2207364..2208248 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
NFJ18_RS10850 (2208241) 2208241..2208894 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
NFJ18_RS10855 (2208945) 2208945..2209229 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
NFJ18_RS10860 (2209229) 2209229..2209507 - 279 WP_104919749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ18_RS10865 (2209693) 2209693..2210703 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
NFJ18_RS10870 (2210837) 2210837..2212534 - 1698 WP_181203469.1 malate dehydrogenase -
NFJ18_RS10875 (2212691) 2212691..2212828 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
NFJ18_RS10880 (2212930) 2212930..2213145 - 216 WP_000495766.1 biofilm-dependent modulation protein -
NFJ18_RS10885 (2213487) 2213487..2213918 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T248615 WP_104919749.1 NZ_CP099358:c2209507-2209229 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT248615 WP_000781370.1 NZ_CP099358:c2209229-2208945 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References