Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 1104761..1105440 Replicon chromosome
Accession NZ_CP099358
Organism Escherichia fergusonii strain RHB02-E1-C03

Toxin (Protein)


Gene name higB Uniprot ID B7LJF3
Locus tag NFJ18_RS05465 Protein ID WP_002431667.1
Coordinates 1104761..1105063 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFJ18_RS05470 Protein ID WP_000806441.1
Coordinates 1105099..1105440 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ18_RS05440 (1100137) 1100137..1101789 + 1653 WP_181203208.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
NFJ18_RS05445 (1101827) 1101827..1102330 - 504 WP_000667001.1 hypothetical protein -
NFJ18_RS05450 (1102327) 1102327..1102983 - 657 WP_181674165.1 hypothetical protein -
NFJ18_RS05455 (1103151) 1103151..1103630 - 480 WP_181203209.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
NFJ18_RS05460 (1103834) 1103834..1104628 - 795 WP_000365145.1 TraB/GumN family protein -
NFJ18_RS05465 (1104761) 1104761..1105063 + 303 WP_002431667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ18_RS05470 (1105099) 1105099..1105440 + 342 WP_000806441.1 HigA family addiction module antitoxin Antitoxin
NFJ18_RS05475 (1105554) 1105554..1108058 - 2505 WP_000083966.1 copper-exporting P-type ATPase CopA -
NFJ18_RS05480 (1108365) 1108365..1109654 + 1290 WP_000102764.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11811.37 Da        Isoelectric Point: 10.1572

>T248609 WP_002431667.1 NZ_CP099358:1104761-1105063 [Escherichia fergusonii]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELYLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13143.01 Da        Isoelectric Point: 5.2345

>AT248609 WP_000806441.1 NZ_CP099358:1105099-1105440 [Escherichia fergusonii]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVADYLARREERAKNVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7K4HYG8

Antitoxin

Source ID Structure

References