Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 870276..870522 Replicon chromosome
Accession NZ_CP099358
Organism Escherichia fergusonii strain RHB02-E1-C03

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag NFJ18_RS04245 Protein ID WP_000956458.1
Coordinates 870370..870522 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 870276..870328 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ18_RS04230 865784..867583 + 1800 WP_181203169.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
NFJ18_RS04235 867583..869295 + 1713 WP_115738177.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
NFJ18_RS04240 869369..870103 + 735 WP_181203170.1 phosphoadenosine phosphosulfate reductase -
- 870276..870328 - 53 - - Antitoxin
NFJ18_RS04245 870370..870522 + 153 WP_000956458.1 Hok/Gef family protein Toxin
NFJ18_RS04250 870715..873415 + 2701 Protein_819 CRISPR-associated helicase Cas3' -
NFJ18_RS04255 873513..875075 + 1563 WP_181203171.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T248608 WP_000956458.1 NZ_CP099358:870370-870522 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

Antitoxin


Download         Length: 53 bp

>AT248608 NZ_CP099358:c870328-870276 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References