Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 568911..569169 Replicon chromosome
Accession NZ_CP099358
Organism Escherichia fergusonii strain RHB02-E1-C03

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NFJ18_RS02875 Protein ID WP_000809168.1
Coordinates 568911..569063 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 569112..569169 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ18_RS02855 563977..564564 + 588 WP_002431696.1 molybdopterin adenylyltransferase -
NFJ18_RS02860 564598..565164 - 567 WP_000528529.1 acetate uptake transporter -
NFJ18_RS02865 565672..567588 + 1917 WP_000516135.1 molecular chaperone DnaK -
NFJ18_RS02870 567677..568807 + 1131 WP_001118464.1 molecular chaperone DnaJ -
NFJ18_RS02875 568911..569063 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 569112..569169 + 58 - - Antitoxin
NFJ18_RS02880 569604..570770 + 1167 WP_000681374.1 Na+/H+ antiporter NhaA -
NFJ18_RS02885 570838..571737 + 900 WP_000019049.1 transcriptional activator NhaR -
NFJ18_RS02890 571833..572096 - 264 WP_001274021.1 30S ribosomal protein S20 -
NFJ18_RS02895 572199..572417 + 219 WP_181203115.1 DUF2575 domain-containing protein -
NFJ18_RS02900 572425..573366 + 942 WP_000767329.1 bifunctional riboflavin kinase/FAD synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T248607 WP_000809168.1 NZ_CP099358:c569063-568911 [Escherichia fergusonii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT248607 NZ_CP099358:569112-569169 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References