Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 437820..438619 Replicon chromosome
Accession NZ_CP099358
Organism Escherichia fergusonii strain RHB02-E1-C03

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag NFJ18_RS02105 Protein ID WP_000347270.1
Coordinates 437820..438284 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag NFJ18_RS02110 Protein ID WP_104919918.1
Coordinates 438284..438619 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ18_RS02075 (432821) 432821..433255 - 435 WP_032303830.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NFJ18_RS02080 (433273) 433273..434151 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NFJ18_RS02085 (434141) 434141..434920 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NFJ18_RS02090 (434931) 434931..435404 - 474 WP_032303829.1 PTS N-acetylgalactosamine transporter subunit IIB -
NFJ18_RS02095 (435427) 435427..436707 - 1281 WP_181203097.1 tagatose-bisphosphate aldolase subunit KbaZ -
NFJ18_RS02100 (436956) 436956..437765 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NFJ18_RS02105 (437820) 437820..438284 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NFJ18_RS02110 (438284) 438284..438619 - 336 WP_104919918.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NFJ18_RS02115 (438768) 438768..440339 - 1572 WP_181203098.1 galactarate dehydratase -
NFJ18_RS02120 (440810) 440810..441580 + 771 WP_001058567.1 2-dehydro-3-deoxyglucarate aldolase -
NFJ18_RS02125 (441605) 441605..442495 + 891 WP_000178100.1 2-hydroxy-3-oxopropionate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T248606 WP_000347270.1 NZ_CP099358:c438284-437820 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12349.93 Da        Isoelectric Point: 4.5392

>AT248606 WP_104919918.1 NZ_CP099358:c438619-438284 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGRKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure

References