Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2268453..2269015 Replicon chromosome
Accession NZ_CP099351
Organism Escherichia marmotae strain RHB02-E4-C07

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFJ26_RS10705 Protein ID WP_000605672.1
Coordinates 2268453..2268731 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag NFJ26_RS10710 Protein ID WP_000781370.1
Coordinates 2268731..2269015 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ26_RS10680 (2264073) 2264073..2264504 - 432 WP_000152293.1 peroxiredoxin OsmC -
NFJ26_RS10685 (2264827) 2264827..2265042 + 216 WP_000495761.1 biofilm-dependent modulation protein -
NFJ26_RS10690 (2265133) 2265133..2265270 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
NFJ26_RS10695 (2265426) 2265426..2267123 + 1698 WP_000433452.1 malate dehydrogenase -
NFJ26_RS10700 (2267257) 2267257..2268267 + 1011 WP_000642389.1 alcohol dehydrogenase AdhP -
NFJ26_RS10705 (2268453) 2268453..2268731 + 279 WP_000605672.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ26_RS10710 (2268731) 2268731..2269015 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
NFJ26_RS10715 (2269243) 2269243..2269896 - 654 WP_000045637.1 formate dehydrogenase-N subunit gamma -
NFJ26_RS10720 (2269889) 2269889..2270773 - 885 WP_001240589.1 formate dehydrogenase N subunit beta -
NFJ26_RS10725 (2270786) 2270786..2273833 - 3048 WP_077633351.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10650.26 Da        Isoelectric Point: 7.3563

>T248600 WP_000605672.1 NZ_CP099351:2268453-2268731 [Escherichia marmotae]
MIMNFRHKGLRDLFLLGKTSGVIPKQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDEIWTISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT248600 WP_000781370.1 NZ_CP099351:2268731-2269015 [Escherichia marmotae]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References