Detailed information of TA system TA248593

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 676777..677035
• Replicon: chromosome
• Accession: NZ_CP099351
• Organism: Escherichia marmotae strain RHB02-E4-C07

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: NFJ26_RS03150
• Protein ID: WP_000809168.1
• Coordinates: 676777..676929 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	676978..677035 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NFJ26_RS03120	671955..672053	-	99	Protein_601	hypothetical protein	-
NFJ26_RS03125	672102..672668	-	567	WP_000528538.1	acetate uptake transporter	-
NFJ26_RS03130	672817..672930	-	114	Protein_603	hypothetical protein	-
NFJ26_RS03135	672941..673160	-	220	Protein_604	DUF2541 family protein	-
NFJ26_RS03140	673537..675453	+	1917	WP_000516135.1	molecular chaperone DnaK	-
NFJ26_RS03145	675542..676672	+	1131	WP_001118463.1	molecular chaperone DnaJ	-
NFJ26_RS03150	676777..676929	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	676978..677035	+	58	-	-	Antitoxin
NFJ26_RS03155	677513..678679	+	1167	WP_000681378.1	Na+/H+ antiporter NhaA	-
NFJ26_RS03160	678739..679644	+	906	WP_000062876.1	transcriptional activator NhaR	-
NFJ26_RS03165	679747..680010	-	264	WP_001274018.1	30S ribosomal protein S20	-
NFJ26_RS03170	680113..680331	+	219	Protein_611	DUF2575 domain-containing protein	-
NFJ26_RS03175	680339..681280	+	942	WP_000767344.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T248593 WP_000809168.1 NZ_CP099351:c676929-676777 [Escherichia marmotae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 58 bp

>AT248593 NZ_CP099351:676978-677035 [Escherichia marmotae]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin