Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4035705..4036384 Replicon chromosome
Accession NZ_CP099349
Organism Escherichia fergusonii strain RHB16-E2-C07

Toxin (Protein)


Gene name higB Uniprot ID B7LJF3
Locus tag NFJ86_RS19520 Protein ID WP_002431667.1
Coordinates 4035705..4036007 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFJ86_RS19525 Protein ID WP_000806441.1
Coordinates 4036043..4036384 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ86_RS19495 (4031081) 4031081..4032733 + 1653 WP_181203208.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
NFJ86_RS19500 (4032771) 4032771..4033274 - 504 WP_000667001.1 hypothetical protein -
NFJ86_RS19505 (4033271) 4033271..4033927 - 657 WP_181674165.1 hypothetical protein -
NFJ86_RS19510 (4034095) 4034095..4034574 - 480 WP_181203209.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
NFJ86_RS19515 (4034778) 4034778..4035572 - 795 WP_000365145.1 TraB/GumN family protein -
NFJ86_RS19520 (4035705) 4035705..4036007 + 303 WP_002431667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ86_RS19525 (4036043) 4036043..4036384 + 342 WP_000806441.1 HigA family addiction module antitoxin Antitoxin
NFJ86_RS19530 (4036498) 4036498..4039002 - 2505 WP_000083966.1 copper-exporting P-type ATPase CopA -
NFJ86_RS19535 (4039309) 4039309..4040598 + 1290 WP_000102764.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11811.37 Da        Isoelectric Point: 10.1572

>T248587 WP_002431667.1 NZ_CP099349:4035705-4036007 [Escherichia fergusonii]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELYLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13143.01 Da        Isoelectric Point: 5.2345

>AT248587 WP_000806441.1 NZ_CP099349:4036043-4036384 [Escherichia fergusonii]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVADYLARREERAKNVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7K4HYG8

Antitoxin

Source ID Structure

References