Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3826479..3826725 Replicon chromosome
Accession NZ_CP099349
Organism Escherichia fergusonii strain RHB16-E2-C07

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag NFJ86_RS18465 Protein ID WP_000956458.1
Coordinates 3826573..3826725 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 3826479..3826531 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ86_RS18450 3821987..3823786 + 1800 WP_181203169.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
NFJ86_RS18455 3823786..3825498 + 1713 WP_115738177.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
NFJ86_RS18460 3825572..3826306 + 735 WP_046083134.1 phosphoadenosine phosphosulfate reductase -
- 3826479..3826531 - 53 - - Antitoxin
NFJ86_RS18465 3826573..3826725 + 153 WP_000956458.1 Hok/Gef family protein Toxin
NFJ86_RS18470 3826918..3828030 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -
NFJ86_RS18475 3828267..3830967 + 2701 Protein_3597 CRISPR-associated helicase Cas3' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T248586 WP_000956458.1 NZ_CP099349:3826573-3826725 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

Antitoxin


Download         Length: 53 bp

>AT248586 NZ_CP099349:c3826531-3826479 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References