Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3524932..3525190 Replicon chromosome
Accession NZ_CP099349
Organism Escherichia fergusonii strain RHB16-E2-C07

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NFJ86_RS17095 Protein ID WP_000809168.1
Coordinates 3524932..3525084 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3525133..3525190 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ86_RS17075 3519998..3520585 + 588 WP_002431696.1 molybdopterin adenylyltransferase -
NFJ86_RS17080 3520619..3521185 - 567 WP_000528529.1 acetate uptake transporter -
NFJ86_RS17085 3521693..3523609 + 1917 WP_000516135.1 molecular chaperone DnaK -
NFJ86_RS17090 3523698..3524828 + 1131 WP_001118464.1 molecular chaperone DnaJ -
NFJ86_RS17095 3524932..3525084 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3525133..3525190 + 58 - - Antitoxin
NFJ86_RS17100 3525625..3526791 + 1167 WP_000681374.1 Na+/H+ antiporter NhaA -
NFJ86_RS17105 3526859..3527758 + 900 WP_000019049.1 transcriptional activator NhaR -
NFJ86_RS17110 3527854..3528117 - 264 WP_001274021.1 30S ribosomal protein S20 -
NFJ86_RS17115 3528220..3528438 + 219 WP_181203115.1 DUF2575 domain-containing protein -
NFJ86_RS17120 3528446..3529387 + 942 WP_000767329.1 bifunctional riboflavin kinase/FAD synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T248585 WP_000809168.1 NZ_CP099349:c3525084-3524932 [Escherichia fergusonii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT248585 NZ_CP099349:3525133-3525190 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References