Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3438627..3439426 Replicon chromosome
Accession NZ_CP099349
Organism Escherichia fergusonii strain RHB16-E2-C07

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag NFJ86_RS16625 Protein ID WP_000347270.1
Coordinates 3438627..3439091 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag NFJ86_RS16630 Protein ID WP_104919918.1
Coordinates 3439091..3439426 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ86_RS16595 (3433628) 3433628..3434062 - 435 WP_032303830.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NFJ86_RS16600 (3434080) 3434080..3434958 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NFJ86_RS16605 (3434948) 3434948..3435727 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NFJ86_RS16610 (3435738) 3435738..3436211 - 474 WP_032303829.1 PTS N-acetylgalactosamine transporter subunit IIB -
NFJ86_RS16615 (3436234) 3436234..3437514 - 1281 WP_181203097.1 tagatose-bisphosphate aldolase subunit KbaZ -
NFJ86_RS16620 (3437763) 3437763..3438572 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NFJ86_RS16625 (3438627) 3438627..3439091 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NFJ86_RS16630 (3439091) 3439091..3439426 - 336 WP_104919918.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NFJ86_RS16635 (3439575) 3439575..3441146 - 1572 WP_181668631.1 galactarate dehydratase -
NFJ86_RS16640 (3441617) 3441617..3442387 + 771 WP_001058567.1 2-dehydro-3-deoxyglucarate aldolase -
NFJ86_RS16645 (3442412) 3442412..3443302 + 891 WP_000178100.1 2-hydroxy-3-oxopropionate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T248584 WP_000347270.1 NZ_CP099349:c3439091-3438627 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12349.93 Da        Isoelectric Point: 4.5392

>AT248584 WP_104919918.1 NZ_CP099349:c3439426-3439091 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGRKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure

References