Detailed information of TA system TA248582

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2610819..2611077
• Replicon: chromosome
• Accession: NZ_CP099349
• Organism: Escherichia fergusonii strain RHB16-E2-C07

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: NFJ86_RS12730
• Protein ID: WP_181202950.1
• Coordinates: 2610819..2610971 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2611022..2611077 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NFJ86_RS12700	2606683..2607393	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
NFJ86_RS12705	2607831..2609201	+	1371	WP_000184983.1	MFS transporter	-
NFJ86_RS12710	2609451..2609741	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
NFJ86_RS12715	2610023..2610235	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
NFJ86_RS12720	2610289..2610660	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
NFJ86_RS12725	2610771..2610842	+	72	WP_216665726.1	hypothetical protein	-
NFJ86_RS12730	2610819..2610971	-	153	WP_181202950.1	type I toxin-antitoxin system toxin HokA	Toxin
-	2611022..2611077	+	56	-	-	Antitoxin
NFJ86_RS12735	2611272..2611631	-	360	WP_141095883.1	hypothetical protein	-
NFJ86_RS12740	2611700..2613769	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
NFJ86_RS12745	2613779..2614690	-	912	WP_181202951.1	glycine--tRNA ligase subunit alpha	-
NFJ86_RS12750	2614786..2615085	-	300	WP_024256552.1	YsaB family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5926.17 Da
• Isoelectric Point: 6.9160

>T248582 WP_181202950.1 NZ_CP099349:c2610971-2610819 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT248582 NZ_CP099349:2611022-2611077 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin