Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 481359..481921 Replicon chromosome
Accession NZ_CP099349
Organism Escherichia fergusonii strain RHB16-E2-C07

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFJ86_RS02395 Protein ID WP_104919749.1
Coordinates 481643..481921 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag NFJ86_RS02390 Protein ID WP_000781370.1
Coordinates 481359..481643 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ86_RS02375 (476718) 476718..479765 + 3048 WP_015953395.1 formate dehydrogenase-N subunit alpha -
NFJ86_RS02380 (479778) 479778..480662 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
NFJ86_RS02385 (480655) 480655..481308 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
NFJ86_RS02390 (481359) 481359..481643 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
NFJ86_RS02395 (481643) 481643..481921 - 279 WP_104919749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ86_RS02400 (482107) 482107..483117 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
NFJ86_RS02405 (483251) 483251..484948 - 1698 WP_181203469.1 malate dehydrogenase -
NFJ86_RS02410 (485105) 485105..485242 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
NFJ86_RS02415 (485344) 485344..485559 - 216 WP_000495766.1 biofilm-dependent modulation protein -
NFJ86_RS02420 (485901) 485901..486332 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T248575 WP_104919749.1 NZ_CP099349:c481921-481643 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT248575 WP_000781370.1 NZ_CP099349:c481643-481359 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References