Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 616833..617395 Replicon chromosome
Accession NZ_CP099344
Organism Escherichia marmotae strain RHB35-E2-C08

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFK54_RS03190 Protein ID WP_279283426.1
Coordinates 616833..617111 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag NFK54_RS03195 Protein ID WP_000781370.1
Coordinates 617111..617395 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK54_RS03165 (612453) 612453..612884 - 432 WP_000152293.1 peroxiredoxin OsmC -
NFK54_RS03170 (613207) 613207..613422 + 216 WP_000495761.1 biofilm-dependent modulation protein -
NFK54_RS03175 (613513) 613513..613650 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
NFK54_RS03180 (613806) 613806..615503 + 1698 WP_001516384.1 malate dehydrogenase -
NFK54_RS03185 (615637) 615637..616647 + 1011 WP_000642389.1 alcohol dehydrogenase AdhP -
NFK54_RS03190 (616833) 616833..617111 + 279 WP_279283426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK54_RS03195 (617111) 617111..617395 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
NFK54_RS03200 (617623) 617623..618276 - 654 WP_000045637.1 formate dehydrogenase-N subunit gamma -
NFK54_RS03205 (618269) 618269..619153 - 885 WP_001240589.1 formate dehydrogenase N subunit beta -
NFK54_RS03210 (619166) 619166..622213 - 3048 WP_105281958.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10565.16 Da        Isoelectric Point: 7.3563

>T248554 WP_279283426.1 NZ_CP099344:616833-617111 [Escherichia marmotae]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDEIWTISVSGNWRITFEFVN
GDAYILDYEGYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT248554 WP_000781370.1 NZ_CP099344:617111-617395 [Escherichia marmotae]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References