Detailed information of TA system TA248539

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4259235..4259492
• Replicon: chromosome
• Accession: NZ_CP099338
• Organism: Escherichia fergusonii strain RHB44-C01

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: NFK94_RS20645
• Protein ID: WP_001135731.1
• Coordinates: 4259235..4259387 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4259444..4259492 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NFK94_RS20615	4255101..4255811	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
NFK94_RS20620	4256249..4257619	+	1371	WP_104920428.1	MFS transporter	-
NFK94_RS20625	4257869..4258159	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
NFK94_RS20630	4258440..4258652	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
NFK94_RS20635	4258706..4259077	-	372	WP_104920427.1	membrane protein insertion efficiency factor YidD	-
NFK94_RS20640	4259187..4259258	+	72	WP_216665726.1	hypothetical protein	-
NFK94_RS20645	4259235..4259387	-	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4259444..4259492	+	49	-	-	Antitoxin
NFK94_RS20650	4259709..4261778	-	2070	WP_264783749.1	glycine--tRNA ligase subunit beta	-
NFK94_RS20655	4261788..4262699	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
NFK94_RS20660	4262795..4263094	-	300	WP_024256552.1	YsaB family lipoprotein	-
NFK94_RS20665	4263266..4264261	+	996	WP_002432855.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T248539 WP_001135731.1 NZ_CP099338:c4259387-4259235 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 49 bp

>AT248539 NZ_CP099338:4259444-4259492 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin