Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2170889..2171451 Replicon chromosome
Accession NZ_CP099338
Organism Escherichia fergusonii strain RHB44-C01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFK94_RS10360 Protein ID WP_104919749.1
Coordinates 2171173..2171451 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag NFK94_RS10355 Protein ID WP_000781370.1
Coordinates 2170889..2171173 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK94_RS10340 (2166248) 2166248..2169295 + 3048 WP_141095958.1 formate dehydrogenase-N subunit alpha -
NFK94_RS10345 (2169308) 2169308..2170192 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
NFK94_RS10350 (2170185) 2170185..2170838 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
NFK94_RS10355 (2170889) 2170889..2171173 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
NFK94_RS10360 (2171173) 2171173..2171451 - 279 WP_104919749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK94_RS10365 (2171637) 2171637..2172647 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
NFK94_RS10370 (2172782) 2172782..2174479 - 1698 WP_046077566.1 malate dehydrogenase -
NFK94_RS10375 (2174636) 2174636..2174773 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
NFK94_RS10380 (2174875) 2174875..2175090 - 216 WP_000495766.1 biofilm-dependent modulation protein -
NFK94_RS10385 (2175433) 2175433..2175864 + 432 WP_000152299.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T248531 WP_104919749.1 NZ_CP099338:c2171451-2171173 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT248531 WP_000781370.1 NZ_CP099338:c2171173-2170889 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References