Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 1222057..1222736 Replicon chromosome
Accession NZ_CP099338
Organism Escherichia fergusonii strain RHB44-C01

Toxin (Protein)


Gene name higB Uniprot ID B7LJF3
Locus tag NFK94_RS05990 Protein ID WP_002431667.1
Coordinates 1222057..1222359 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFK94_RS05995 Protein ID WP_000806440.1
Coordinates 1222395..1222736 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK94_RS05965 (1217433) 1217433..1219085 + 1653 WP_160193899.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
NFK94_RS05970 (1219123) 1219123..1219626 - 504 WP_000667001.1 hypothetical protein -
NFK94_RS05975 (1219623) 1219623..1220423 - 801 WP_160193901.1 hypothetical protein -
NFK94_RS05980 (1220447) 1220447..1220926 - 480 WP_000186628.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
NFK94_RS05985 (1221130) 1221130..1221924 - 795 WP_046081753.1 TraB/GumN family protein -
NFK94_RS05990 (1222057) 1222057..1222359 + 303 WP_002431667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK94_RS05995 (1222395) 1222395..1222736 + 342 WP_000806440.1 HigA family addiction module antitoxin Antitoxin
NFK94_RS06000 (1222850) 1222850..1225354 - 2505 WP_000083946.1 copper-exporting P-type ATPase CopA -
NFK94_RS06005 (1225661) 1225661..1226950 + 1290 WP_000102764.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11811.37 Da        Isoelectric Point: 10.1572

>T248526 WP_002431667.1 NZ_CP099338:1222057-1222359 [Escherichia fergusonii]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELYLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13157.08 Da        Isoelectric Point: 5.7737

>AT248526 WP_000806440.1 NZ_CP099338:1222395-1222736 [Escherichia fergusonii]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVADYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7K4HYG8

Antitoxin

Source ID Structure

References