Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1004065..1004311 Replicon chromosome
Accession NZ_CP099338
Organism Escherichia fergusonii strain RHB44-C01

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag NFK94_RS04885 Protein ID WP_000956458.1
Coordinates 1004159..1004311 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 1004065..1004117 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK94_RS04870 999573..1001372 + 1800 WP_104920142.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
NFK94_RS04875 1001372..1003084 + 1713 WP_104920141.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
NFK94_RS04880 1003158..1003892 + 735 WP_046083134.1 phosphoadenosine phosphosulfate reductase -
- 1004065..1004117 - 53 - - Antitoxin
NFK94_RS04885 1004159..1004311 + 153 WP_000956458.1 Hok/Gef family protein Toxin
NFK94_RS04890 1004504..1007204 + 2701 Protein_946 CRISPR-associated helicase Cas3' -
NFK94_RS04895 1007670..1009232 + 1563 WP_104920139.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T248525 WP_000956458.1 NZ_CP099338:1004159-1004311 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

Antitoxin


Download         Length: 53 bp

>AT248525 NZ_CP099338:c1004117-1004065 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References