Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 605760..606559 Replicon chromosome
Accession NZ_CP099338
Organism Escherichia fergusonii strain RHB44-C01

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag NFK94_RS02970 Protein ID WP_000347270.1
Coordinates 605760..606224 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag NFK94_RS02975 Protein ID WP_104919918.1
Coordinates 606224..606559 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK94_RS02940 (600761) 600761..601195 - 435 WP_032303830.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NFK94_RS02945 (601213) 601213..602091 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NFK94_RS02950 (602081) 602081..602860 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NFK94_RS02955 (602871) 602871..603344 - 474 WP_032303829.1 PTS N-acetylgalactosamine transporter subunit IIB -
NFK94_RS02960 (603367) 603367..604647 - 1281 WP_104917761.1 tagatose-bisphosphate aldolase subunit KbaZ -
NFK94_RS02965 (604896) 604896..605705 + 810 WP_279279767.1 aga operon transcriptional regulator AgaR -
NFK94_RS02970 (605760) 605760..606224 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NFK94_RS02975 (606224) 606224..606559 - 336 WP_104919918.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NFK94_RS02980 (606708) 606708..608279 - 1572 WP_104919919.1 galactarate dehydratase -
NFK94_RS02985 (608750) 608750..609520 + 771 WP_001058567.1 2-dehydro-3-deoxyglucarate aldolase -
NFK94_RS02990 (609545) 609545..610435 + 891 WP_000178100.1 2-hydroxy-3-oxopropionate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T248521 WP_000347270.1 NZ_CP099338:c606224-605760 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12349.93 Da        Isoelectric Point: 4.5392

>AT248521 WP_104919918.1 NZ_CP099338:c606559-606224 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGRKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure

References