Detailed information of TA system TA024849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 5276464..5277244
• Replicon: chromosome
• Accession: NC_014323
• Organism: Herbaspirillum seropedicae SmR1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: D8IX29
• Locus tag: HSERO_RS23000
• Protein ID: WP_013236519.1
• Coordinates: 5276948..5277244 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: HSERO_RS22995
• Protein ID: WP_013236518.1
• Coordinates: 5276464..5276946 (-)
• Length: 161 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSERO_RS22975	5271629..5273191	-	1563	WP_041311350.1	MCP four helix bundle domain-containing protein	-
HSERO_RS22980	5273347..5274183	-	837	WP_013236515.1	amidohydrolase family protein	-
HSERO_RS22985	5274180..5275421	-	1242	WP_013236516.1	MFS transporter	-
HSERO_RS22990	5275722..5276456	+	735	WP_013236517.1	GntR family transcriptional regulator	-
HSERO_RS22995	5276464..5276946	-	483	WP_013236518.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HSERO_RS23000	5276948..5277244	-	297	WP_013236519.1	type II toxin-antitoxin system MqsR family toxin	Toxin
HSERO_RS23005	5277681..5278358	+	678	WP_013236520.1	glutathione transferase	-
HSERO_RS23010	5278464..5279720	-	1257	WP_013236521.1	MFS transporter	-
HSERO_RS23015	5280182..5280904	+	723	WP_013236522.1	FadR family transcriptional regulator	-
HSERO_RS23020	5280988..5281791	-	804	WP_013236523.1	transporter substrate-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10911.76 Da
• Isoelectric Point: 9.4837

>T24849 WP_013236519.1 NC_014323:c5277244-5276948 [Herbaspirillum seropedicae SmR1]
MEKHTPHYKLAVVKSLLRQGQVRKTATALLGAAALGIDEMEMVAVVASLSSADFCKSMTTRADHRIWQDVYRPATRYGVL
YVKLTVLDDVLIVSFKES

Nucleotide

• Length: 297 bp

>T24849 NC_014323:c5277244-5276948 [Herbaspirillum seropedicae SmR1]
ATGGAAAAACATACCCCACATTACAAGCTTGCAGTCGTGAAGTCCCTGCTCAGGCAGGGGCAGGTCCGCAAAACGGCGAC
CGCTCTTCTCGGTGCGGCGGCACTGGGCATCGATGAAATGGAAATGGTGGCCGTCGTCGCATCGTTGAGCAGCGCAGATT
TCTGCAAGAGCATGACCACCCGTGCTGATCACCGTATCTGGCAAGACGTCTATCGGCCTGCCACCCGCTACGGTGTCCTC
TACGTCAAGTTGACCGTGCTTGATGATGTGCTGATCGTATCCTTCAAGGAGAGCTGA

Antitoxin

Protein

• Length: 161 a.a.
• Molecular weight: 17455.06 Da
• Isoelectric Point: 8.3546

>AT24849 WP_013236518.1 NC_014323:c5276946-5276464 [Herbaspirillum seropedicae SmR1]
MKCPHCGGAHLIRDTRDLPYAYKGETTVIATVTGDYCPRCGECLPTIEEEARISAEALAFNKEINAGMIDPAEIISTREA
LQLGQREASLLFGGGINAFNRYEAGKIQPPRALVLLLRLLRKHPELLSELRADAGMSARGQAVHSVQEAGAGRLRTRSRK

Nucleotide

• Length: 483 bp

>AT24849 NC_014323:c5276946-5276464 [Herbaspirillum seropedicae SmR1]
ATGAAATGTCCCCATTGCGGAGGCGCGCACCTGATCCGCGACACGCGCGATCTGCCCTATGCCTACAAGGGCGAAACCAC
GGTCATTGCGACGGTCACCGGCGACTATTGCCCGCGCTGCGGCGAGTGTCTGCCGACCATCGAAGAAGAAGCCAGGATCT
CGGCCGAGGCGCTGGCCTTCAATAAGGAAATCAACGCCGGGATGATCGATCCCGCCGAAATCATCTCTACCCGCGAGGCC
CTGCAACTGGGCCAGCGCGAGGCCAGCCTGCTGTTCGGCGGAGGGATCAATGCCTTCAACCGCTATGAGGCCGGCAAGAT
CCAGCCGCCGCGTGCGCTGGTGCTGTTGTTGCGCCTGTTGCGCAAGCACCCGGAGTTGCTCAGTGAACTGCGCGCCGACG
CCGGCATGAGCGCGCGTGGCCAGGCCGTCCATTCGGTCCAGGAAGCCGGCGCCGGCCGCTTGCGGACCCGCTCGCGCAAG
TGA

Structures

Toxin

• AlphaFold DB: D8IX29