Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 663268..663526 Replicon chromosome
Accession NZ_CP099331
Organism Escherichia fergusonii strain RHB44-C03

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NFK96_RS03295 Protein ID WP_000809168.1
Coordinates 663268..663420 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 663469..663526 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK96_RS03275 658334..658921 + 588 WP_002431696.1 molybdopterin adenylyltransferase -
NFK96_RS03280 658955..659521 - 567 WP_000528529.1 acetate uptake transporter -
NFK96_RS03285 660029..661945 + 1917 WP_000516135.1 molecular chaperone DnaK -
NFK96_RS03290 662034..663164 + 1131 WP_001118464.1 molecular chaperone DnaJ -
NFK96_RS03295 663268..663420 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 663469..663526 + 58 - - Antitoxin
NFK96_RS03300 663961..665127 + 1167 WP_000681374.1 Na+/H+ antiporter NhaA -
NFK96_RS03305 665195..666094 + 900 WP_000019049.1 transcriptional activator NhaR -
NFK96_RS03310 666190..666453 - 264 WP_001274021.1 30S ribosomal protein S20 -
NFK96_RS03315 666556..666774 + 219 WP_097343043.1 DUF2575 family protein -
NFK96_RS03320 666782..667723 + 942 WP_042021512.1 bifunctional riboflavin kinase/FAD synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T248489 WP_000809168.1 NZ_CP099331:c663420-663268 [Escherichia fergusonii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT248489 NZ_CP099331:663469-663526 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References