Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 553058..553857 Replicon chromosome
Accession NZ_CP099331
Organism Escherichia fergusonii strain RHB44-C03

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag NFK96_RS02640 Protein ID WP_000347270.1
Coordinates 553058..553522 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID B7LMV4
Locus tag NFK96_RS02645 Protein ID WP_015953962.1
Coordinates 553522..553857 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK96_RS02610 (548060) 548060..548494 - 435 WP_000948832.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NFK96_RS02615 (548512) 548512..549390 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NFK96_RS02620 (549380) 549380..550159 - 780 WP_223684419.1 PTS N-acetylgalactosamine transporter subunit IIC -
NFK96_RS02625 (550170) 550170..550643 - 474 WP_032303829.1 PTS N-acetylgalactosamine transporter subunit IIB -
NFK96_RS02630 (550666) 550666..551946 - 1281 WP_223684406.1 tagatose-bisphosphate aldolase subunit KbaZ -
NFK96_RS02635 (552194) 552194..553003 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NFK96_RS02640 (553058) 553058..553522 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NFK96_RS02645 (553522) 553522..553857 - 336 WP_015953962.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NFK96_RS02650 (554006) 554006..555577 - 1572 WP_223684407.1 galactarate dehydratase -
NFK96_RS02655 (556048) 556048..556818 + 771 WP_279284675.1 2-dehydro-3-deoxyglucarate aldolase -
NFK96_RS02660 (556843) 556843..557733 + 891 WP_223684408.1 2-hydroxy-3-oxopropionate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T248488 WP_000347270.1 NZ_CP099331:c553522-553058 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12281.89 Da        Isoelectric Point: 4.4128

>AT248488 WP_015953962.1 NZ_CP099331:c553857-553522 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDPTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB B7LMV4

References