Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 74686..75257 Replicon plasmid unnamed2
Accession NZ_CP099330
Organism Escherichia fergusonii strain RHB44-C21

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFL02_RS23080 Protein ID WP_279284509.1
Coordinates 74976..75257 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFL02_RS23075 Protein ID WP_279284508.1
Coordinates 74686..74967 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL02_RS23050 (NFL02_23025) 70619..71386 - 768 WP_279284502.1 baseplate -
NFL02_RS23055 (NFL02_23030) 71383..72174 - 792 WP_279284503.1 phage tail protein -
NFL02_RS23060 (NFL02_23035) 72326..72865 + 540 WP_279284504.1 stationary phase growth adaptation protein -
NFL02_RS23065 (NFL02_23040) 73067..74272 - 1206 WP_279284505.1 phage tail protein -
NFL02_RS23070 (NFL02_23045) 74265..74594 - 330 WP_279284507.1 baseplate protein -
NFL02_RS23075 (NFL02_23050) 74686..74967 - 282 WP_279284508.1 HigA family addiction module antitoxin Antitoxin
NFL02_RS23080 (NFL02_23055) 74976..75257 - 282 WP_279284509.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFL02_RS23085 (NFL02_23060) 75592..76245 - 654 WP_279284510.1 maturation control protein -
NFL02_RS23090 (NFL02_23065) 76528..77142 + 615 WP_279284511.1 hypothetical protein -
NFL02_RS23095 (NFL02_23070) 77168..77614 + 447 WP_234353651.1 hypothetical protein -
NFL02_RS23100 (NFL02_23075) 77699..77866 - 168 WP_171763956.1 hypothetical protein -
NFL02_RS23105 (NFL02_23080) 77927..78112 - 186 WP_064198788.1 host cell division inhibitor Icd-like protein -
NFL02_RS23110 (NFL02_23085) 78354..78959 - 606 WP_279284512.1 Ref family recombination enhancement nuclease -
NFL02_RS23115 (NFL02_23090) 79080..79232 + 153 WP_279284513.1 hypothetical protein -
NFL02_RS23120 (NFL02_23095) 79232..79819 + 588 WP_279284514.1 DUF4406 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..87952 87952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10590.14 Da        Isoelectric Point: 10.2589

>T248487 WP_279284509.1 NZ_CP099330:c75257-74976 [Escherichia fergusonii]
MIKSFRHKGLERFFKTGTTAGIQAKHAVKLRIQLTALNAAKRPDDMSAPGWELHPLKGADLKGHWAISVNGNWRLTFRFE
GEDAILVDYQDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10114.59 Da        Isoelectric Point: 7.4024

>AT248487 WP_279284508.1 NZ_CP099330:c74967-74686 [Escherichia fergusonii]
MSRMHNPAHPGAVLREYLGDISVTDAAAALGITRTALSRILNEKAGISADMALRLEAALGTSAEMWTGMQSQYELWVASQ
TVRPNIRPLFHHA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References