Detailed information of TA system TA248486

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4355642..4355899
• Replicon: chromosome
• Accession: NZ_CP099328
• Organism: Escherichia fergusonii strain RHB44-C21

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: NFL02_RS20880
• Protein ID: WP_001135723.1
• Coordinates: 4355642..4355794 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4355851..4355899 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NFL02_RS20850	4351506..4352216	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
NFL02_RS20855	4352654..4354024	+	1371	WP_279284063.1	MFS transporter	-
NFL02_RS20860	4354274..4354564	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
NFL02_RS20865	4354846..4355058	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
NFL02_RS20870	4355112..4355483	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
NFL02_RS20875	4355594..4355665	+	72	WP_216665726.1	hypothetical protein	-
NFL02_RS20880	4355642..4355794	-	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4355851..4355899	+	49	-	-	Antitoxin
NFL02_RS20885	4356116..4358185	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
NFL02_RS20890	4358195..4359106	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
NFL02_RS20895	4359202..4359501	-	300	WP_024256552.1	YsaB family lipoprotein	-
NFL02_RS20900	4359673..4360668	+	996	WP_279284064.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T248486 WP_001135723.1 NZ_CP099328:c4355794-4355642 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 49 bp

>AT248486 NZ_CP099328:4355851-4355899 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin