Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4884833..4885406 Replicon chromosome
Accession NC_014323
Organism Herbaspirillum seropedicae SmR1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HSERO_RS21335 Protein ID WP_041312325.1
Coordinates 4885128..4885406 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HSERO_RS21330 Protein ID WP_013236194.1
Coordinates 4884833..4885108 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSERO_RS21310 4879939..4881495 + 1557 WP_013236190.1 ABC transporter ATP-binding protein -
HSERO_RS21315 4881488..4882582 + 1095 WP_013236191.1 ABC transporter permease -
HSERO_RS21320 4882599..4883519 + 921 WP_013236192.1 ABC transporter permease -
HSERO_RS21325 4883592..4884731 + 1140 WP_013236193.1 BMP family ABC transporter substrate-binding protein -
HSERO_RS21330 4884833..4885108 - 276 WP_013236194.1 HigA family addiction module antidote protein Antitoxin
HSERO_RS21335 4885128..4885406 - 279 WP_041312325.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HSERO_RS21340 4885644..4886438 + 795 WP_013236196.1 septum site-determining protein MinC -
HSERO_RS21345 4886521..4887336 + 816 WP_013236197.1 septum site-determining protein MinD -
HSERO_RS21350 4887338..4887607 + 270 WP_006465131.1 cell division topological specificity factor MinE -
HSERO_RS21355 4887735..4888436 + 702 WP_013236198.1 response regulator transcription factor -
HSERO_RS21360 4888640..4889932 + 1293 WP_013236199.1 glutamyl-tRNA reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10328.88 Da        Isoelectric Point: 10.0459

>T24848 WP_041312325.1 NC_014323:c4885406-4885128 [Herbaspirillum seropedicae SmR1]
MIKNFRHKGLQRFFETGSKAGIQAAHAGKLRLQLAALDQATQPEDLSAPAWALHPLKGELKGLWAITVNGNWRLIFAFEG
KDAVLVDYRDYH

Download         Length: 279 bp

>T24848 NC_014323:c4885406-4885128 [Herbaspirillum seropedicae SmR1]
ATGATCAAGAATTTCCGACACAAAGGGCTGCAACGTTTCTTTGAGACGGGCAGCAAGGCTGGCATTCAGGCTGCTCATGC
GGGCAAGCTCAGGCTGCAGCTGGCCGCGCTGGACCAAGCCACCCAACCGGAAGATCTTTCTGCGCCCGCATGGGCGCTGC
ATCCACTAAAAGGTGAGCTCAAGGGGCTATGGGCGATCACCGTCAACGGCAATTGGCGGCTGATATTCGCTTTCGAGGGG
AAGGACGCGGTACTGGTGGATTACCGCGACTATCACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10008.55 Da        Isoelectric Point: 7.2013

>AT24848 WP_013236194.1 NC_014323:c4885108-4884833 [Herbaspirillum seropedicae SmR1]
VNRMFNPPHPGEVLREYLGEMTVTEAAMRLGVSRVTLQRIVNGAAGISPDMAYRLAAAFGTSPELWAGMQLQYDLHAASK
LERPPIERITA

Download         Length: 276 bp

>AT24848 NC_014323:c4885108-4884833 [Herbaspirillum seropedicae SmR1]
GTGAATCGCATGTTCAACCCACCTCACCCTGGCGAGGTGTTGAGGGAATACCTGGGTGAAATGACCGTGACCGAAGCCGC
CATGCGGCTTGGCGTCAGTCGCGTCACCCTGCAACGCATCGTCAACGGCGCAGCTGGCATCTCGCCGGATATGGCCTATC
GCCTGGCGGCTGCCTTTGGCACCAGTCCCGAACTGTGGGCCGGGATGCAGCTGCAATACGATCTGCATGCCGCCAGCAAG
CTGGAGCGCCCACCCATCGAGCGCATCACTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References