Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 1209296..1209975 Replicon chromosome
Accession NZ_CP099328
Organism Escherichia fergusonii strain RHB44-C21

Toxin (Protein)


Gene name higB Uniprot ID B7LJF3
Locus tag NFL02_RS05915 Protein ID WP_002431667.1
Coordinates 1209296..1209598 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFL02_RS05920 Protein ID WP_000806441.1
Coordinates 1209634..1209975 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL02_RS05890 (1204672) 1204672..1206324 + 1653 WP_196082122.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
NFL02_RS05895 (1206362) 1206362..1206865 - 504 WP_279284275.1 hypothetical protein -
NFL02_RS05900 (1206862) 1206862..1207662 - 801 WP_000439795.1 hypothetical protein -
NFL02_RS05905 (1207686) 1207686..1208165 - 480 WP_000186629.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
NFL02_RS05910 (1208369) 1208369..1209163 - 795 WP_046082796.1 TraB/GumN family protein -
NFL02_RS05915 (1209296) 1209296..1209598 + 303 WP_002431667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFL02_RS05920 (1209634) 1209634..1209975 + 342 WP_000806441.1 HigA family addiction module antitoxin Antitoxin
NFL02_RS05925 (1210089) 1210089..1212593 - 2505 WP_279284276.1 copper-exporting P-type ATPase CopA -
NFL02_RS05930 (1212900) 1212900..1214188 + 1289 Protein_1144 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11811.37 Da        Isoelectric Point: 10.1572

>T248468 WP_002431667.1 NZ_CP099328:1209296-1209598 [Escherichia fergusonii]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELYLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13143.01 Da        Isoelectric Point: 5.2345

>AT248468 WP_000806441.1 NZ_CP099328:1209634-1209975 [Escherichia fergusonii]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVADYLARREERAKNVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7K4HYG8

Antitoxin

Source ID Structure

References