Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1005163..1005409 Replicon chromosome
Accession NZ_CP099328
Organism Escherichia fergusonii strain RHB44-C21

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag NFL02_RS04875 Protein ID WP_000956458.1
Coordinates 1005257..1005409 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 1005163..1005215 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL02_RS04860 1000671..1002470 + 1800 WP_181667160.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
NFL02_RS04865 1002470..1004182 + 1713 WP_046083135.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
NFL02_RS04870 1004256..1004990 + 735 WP_046083134.1 phosphoadenosine phosphosulfate reductase -
- 1005163..1005215 - 53 - - Antitoxin
NFL02_RS04875 1005257..1005409 + 153 WP_000956458.1 Hok/Gef family protein Toxin
NFL02_RS04880 1005602..1008302 + 2701 Protein_944 CRISPR-associated helicase Cas3' -
NFL02_RS04885 1008400..1009962 + 1563 WP_001084117.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T248467 WP_000956458.1 NZ_CP099328:1005257-1005409 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

Antitoxin


Download         Length: 53 bp

>AT248467 NZ_CP099328:c1005215-1005163 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References