Detailed information of TA system TA024846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2864673..2865380
• Replicon: chromosome
• Accession: NC_014323
• Organism: Herbaspirillum seropedicae SmR1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: D8IWJ3
• Locus tag: HSERO_RS12565
• Protein ID: WP_013234492.1
• Coordinates: 2865078..2865380 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: HSERO_RS12560
• Protein ID: WP_013234491.1
• Coordinates: 2864673..2865074 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSERO_RS12535	2859771..2860964	+	1194	WP_013234486.1	NO-inducible flavohemoprotein	-
HSERO_RS12540	2861014..2861421	+	408	WP_041311897.1	hemerythrin domain-containing protein	-
HSERO_RS12545	2861598..2861954	+	357	WP_013234488.1	hypothetical protein	-
HSERO_RS12550	2861955..2862947	-	993	WP_013234489.1	2-hydroxyacid dehydrogenase	-
HSERO_RS12555	2863286..2864572	+	1287	WP_013234490.1	MFS transporter	-
HSERO_RS12560	2864673..2865074	-	402	WP_013234491.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HSERO_RS12565	2865078..2865380	-	303	WP_013234492.1	type II toxin-antitoxin system MqsR family toxin	Toxin
HSERO_RS12570	2865719..2867947	+	2229	WP_013234493.1	NADP-dependent isocitrate dehydrogenase	-
HSERO_RS12575	2868243..2869112	-	870	WP_013234494.1	ethanolamine ammonia-lyase subunit EutC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-99)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11105.04 Da
• Isoelectric Point: 9.2564

>T24846 WP_013234492.1 NC_014323:c2865380-2865078 [Herbaspirillum seropedicae SmR1]
MEKHTAHCKLPVVRKLIEAGKVKATATAFQGARACGIGDLDGICAVILGLRPRDFHKSMTTHADHRVWQDVYHARLHNGM
VVYLKLSVVDDVLVVSFKEL

Nucleotide

• Length: 303 bp

>T24846 NC_014323:c2865380-2865078 [Herbaspirillum seropedicae SmR1]
ATGGAGAAGCATACCGCCCACTGCAAGCTGCCCGTGGTCAGGAAACTGATCGAAGCAGGGAAGGTGAAGGCGACCGCTAC
CGCCTTCCAGGGCGCGAGGGCGTGCGGCATCGGGGACCTTGATGGCATCTGCGCGGTGATCCTGGGGCTCAGGCCCCGTG
ACTTCCATAAAAGCATGACGACCCACGCCGACCATCGGGTCTGGCAGGATGTCTACCACGCCAGGCTGCACAATGGCATG
GTGGTTTATCTCAAGCTCAGCGTGGTCGACGACGTGCTGGTGGTTTCCTTCAAGGAGCTTTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14957.10 Da
• Isoelectric Point: 7.1658

>AT24846 WP_013234491.1 NC_014323:c2865074-2864673 [Herbaspirillum seropedicae SmR1]
MKCPCCGAAELVHETRDLPYTYKGESTLIAQVKGDFCPACGEVLLDREHGDRYSELIGQFQRKVNAAYVDPAYIARVRRK
LDLDQREAGELFGGGVNAFSRYENGKTKPPLSLVKLFRLLDRHPDLLDEIRAA

Nucleotide

• Length: 402 bp

>AT24846 NC_014323:c2865074-2864673 [Herbaspirillum seropedicae SmR1]
ATGAAATGTCCTTGCTGCGGCGCAGCCGAACTGGTCCACGAAACACGTGACCTGCCCTATACCTACAAGGGCGAAAGCAC
CCTCATTGCCCAGGTGAAGGGGGACTTCTGTCCTGCCTGCGGCGAAGTCCTGCTCGATCGGGAGCATGGCGACCGCTACA
GCGAACTGATCGGGCAATTCCAGCGCAAGGTGAATGCGGCCTACGTGGACCCCGCCTACATAGCCCGGGTCCGGCGCAAG
CTCGATCTCGACCAGCGCGAGGCAGGCGAGCTCTTCGGCGGCGGCGTCAATGCCTTTTCCCGTTACGAGAACGGCAAGAC
CAAGCCGCCGCTCTCACTGGTCAAGCTGTTCAGGTTGCTGGACCGGCATCCCGACCTGCTGGACGAAATCCGCGCCGCCT
GA

Structures

Toxin

• AlphaFold DB: D8IWJ3