Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4451196..4451798 Replicon chromosome
Accession NZ_CP099323
Organism Enterobacter hormaechei strain RHB45-SO-C08

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFL40_RS21060 Protein ID WP_045308723.1
Coordinates 4451487..4451798 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFL40_RS21055 Protein ID WP_032626927.1
Coordinates 4451196..4451486 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL40_RS21040 (NFL40_21030) 4448694..4449596 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
NFL40_RS21045 (NFL40_21035) 4449593..4450228 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
NFL40_RS21050 (NFL40_21040) 4450225..4451154 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
NFL40_RS21055 (NFL40_21045) 4451196..4451486 - 291 WP_032626927.1 NadS family protein Antitoxin
NFL40_RS21060 (NFL40_21050) 4451487..4451798 - 312 WP_045308723.1 toxin HigB-2 Toxin
NFL40_RS21065 (NFL40_21055) 4451947..4452888 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
NFL40_RS21070 (NFL40_21060) 4452933..4453370 - 438 WP_048965998.1 D-aminoacyl-tRNA deacylase -
NFL40_RS21075 (NFL40_21065) 4453367..4454248 - 882 WP_225303555.1 virulence factor BrkB family protein -
NFL40_RS21080 (NFL40_21070) 4454242..4454841 - 600 WP_003861947.1 glucose-1-phosphatase -
NFL40_RS21085 (NFL40_21075) 4454960..4455760 - 801 WP_048965999.1 DeoR/GlpR family DNA-binding transcription regulator -
NFL40_RS21090 (NFL40_21080) 4455795..4456691 - 897 WP_048966000.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12134.10 Da        Isoelectric Point: 9.4455

>T248449 WP_045308723.1 NZ_CP099323:c4451798-4451487 [Enterobacter hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPDYGDLIQNSGGLRKIRWLAGGKGKRSGVRVIYFHRTRECEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10685.18 Da        Isoelectric Point: 10.5888

>AT248449 WP_032626927.1 NZ_CP099323:c4451486-4451196 [Enterobacter hormaechei]
MDKALFERLTQSIAQINEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References