Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 30065..30795 Replicon chromosome
Accession NZ_CP099323
Organism Enterobacter hormaechei strain RHB45-SO-C08

Toxin (Protein)


Gene name higB Uniprot ID A0A155SSD8
Locus tag NFL40_RS00155 Protein ID WP_022646552.1
Coordinates 30065..30379 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFL40_RS00160 Protein ID WP_023305145.1
Coordinates 30376..30795 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL40_RS00130 (NFL40_00130) 26146..27231 + 1086 Protein_25 cellulase family glycosylhydrolase -
NFL40_RS00135 (NFL40_00135) 27137..28321 - 1185 WP_023298963.1 multidrug efflux MFS transporter EmrD -
NFL40_RS00140 (NFL40_00140) 28497..28915 - 419 Protein_27 EamA family transporter -
NFL40_RS00145 (NFL40_00145) 28978..29424 - 447 WP_023298965.1 GNAT family N-acetyltransferase -
NFL40_RS00150 (NFL40_00150) 29489..29578 - 90 WP_022646551.1 type I toxin-antitoxin system toxin TisB -
NFL40_RS00155 (NFL40_00155) 30065..30379 + 315 WP_022646552.1 type II toxin-antitoxin system HigB family toxin Toxin
NFL40_RS00160 (NFL40_00160) 30376..30795 + 420 WP_023305145.1 helix-turn-helix domain-containing protein Antitoxin
NFL40_RS00165 (NFL40_00165) 30942..31040 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
NFL40_RS00170 (NFL40_00170) 31147..32835 + 1689 WP_048966211.1 acetolactate synthase large subunit -
NFL40_RS00175 (NFL40_00175) 32839..33126 + 288 WP_045336030.1 acetolactate synthase small subunit -
NFL40_RS00180 (NFL40_00180) 33252..33845 + 594 WP_022646555.1 transcriptional regulator UhpA -
NFL40_RS00185 (NFL40_00185) 33842..35347 + 1506 WP_169440842.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-137)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12441.55 Da        Isoelectric Point: 10.1989

>T248439 WP_022646552.1 NZ_CP099323:30065-30379 [Enterobacter hormaechei]
MHLISMKAILDAVSQFPQYREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15508.15 Da        Isoelectric Point: 5.6761

>AT248439 WP_023305145.1 NZ_CP099323:30376-30795 [Enterobacter hormaechei]
MMIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHYEANRPEIVALRKEMESVPVG
IAVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAVRFGVSPALFIE

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155SSD8

Antitoxin

Source ID Structure

References