Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 3593742..3594417 | Replicon | chromosome |
Accession | NZ_CP099316 | ||
Organism | Enterobacter hormaechei strain RHB44-SE-C02 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A837FDC1 |
Locus tag | NFL06_RS17310 | Protein ID | WP_015571638.1 |
Coordinates | 3593742..3594041 (+) | Length | 100 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A2J0PXC9 |
Locus tag | NFL06_RS17315 | Protein ID | WP_015571639.1 |
Coordinates | 3594052..3594417 (+) | Length | 122 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NFL06_RS17300 (NFL06_17285) | 3590119..3592311 | + | 2193 | WP_017692801.1 | type I secretion system permease/ATPase | - |
NFL06_RS17305 (NFL06_17290) | 3592292..3593491 | + | 1200 | WP_017382757.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
NFL06_RS17310 (NFL06_17295) | 3593742..3594041 | + | 300 | WP_015571638.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
NFL06_RS17315 (NFL06_17300) | 3594052..3594417 | + | 366 | WP_015571639.1 | HigA family addiction module antitoxin | Antitoxin |
NFL06_RS17320 (NFL06_17305) | 3594444..3595625 | - | 1182 | WP_017382758.1 | PLP-dependent aminotransferase family protein | - |
NFL06_RS17325 (NFL06_17310) | 3595646..3596533 | - | 888 | WP_015571641.1 | LysR family transcriptional regulator | - |
NFL06_RS17330 (NFL06_17315) | 3596631..3597233 | + | 603 | WP_017382759.1 | short chain dehydrogenase | - |
NFL06_RS17335 (NFL06_17320) | 3597230..3597961 | - | 732 | WP_017382760.1 | methyltransferase domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11624.29 Da Isoelectric Point: 9.6776
>T248425 WP_015571638.1 NZ_CP099316:3593742-3594041 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK
Download Length: 300 bp
Antitoxin
Download Length: 122 a.a. Molecular weight: 13705.73 Da Isoelectric Point: 9.5936
>AT248425 WP_015571639.1 NZ_CP099316:3594052-3594417 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA
Download Length: 366 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837FDC1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J0PXC9 |