Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3593742..3594417 Replicon chromosome
Accession NZ_CP099316
Organism Enterobacter hormaechei strain RHB44-SE-C02

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag NFL06_RS17310 Protein ID WP_015571638.1
Coordinates 3593742..3594041 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag NFL06_RS17315 Protein ID WP_015571639.1
Coordinates 3594052..3594417 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL06_RS17300 (NFL06_17285) 3590119..3592311 + 2193 WP_017692801.1 type I secretion system permease/ATPase -
NFL06_RS17305 (NFL06_17290) 3592292..3593491 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
NFL06_RS17310 (NFL06_17295) 3593742..3594041 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFL06_RS17315 (NFL06_17300) 3594052..3594417 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
NFL06_RS17320 (NFL06_17305) 3594444..3595625 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
NFL06_RS17325 (NFL06_17310) 3595646..3596533 - 888 WP_015571641.1 LysR family transcriptional regulator -
NFL06_RS17330 (NFL06_17315) 3596631..3597233 + 603 WP_017382759.1 short chain dehydrogenase -
NFL06_RS17335 (NFL06_17320) 3597230..3597961 - 732 WP_017382760.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T248425 WP_015571638.1 NZ_CP099316:3593742-3594041 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT248425 WP_015571639.1 NZ_CP099316:3594052-3594417 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References