Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 339581..340227 Replicon chromosome
Accession NZ_CP099260
Organism Klebsiella aerogenes strain RHB08-SO-C04

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFJ54_RS01575 Protein ID WP_045394830.1
Coordinates 339581..339928 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFJ54_RS01580 Protein ID WP_045394831.1
Coordinates 339928..340227 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ54_RS01565 (NFJ54_01565) 335465..336898 + 1434 WP_015369346.1 glycogen synthase GlgA -
NFJ54_RS01570 (NFJ54_01570) 336916..339363 + 2448 WP_015369347.1 glycogen phosphorylase -
NFJ54_RS01575 (NFJ54_01575) 339581..339928 + 348 WP_045394830.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ54_RS01580 (NFJ54_01580) 339928..340227 + 300 WP_045394831.1 XRE family transcriptional regulator Antitoxin
NFJ54_RS01585 (NFJ54_01585) 340573..342081 - 1509 WP_279281335.1 glycerol-3-phosphate dehydrogenase -
NFJ54_RS01590 (NFJ54_01590) 342288..342617 + 330 WP_015369349.1 thiosulfate sulfurtransferase GlpE -
NFJ54_RS01595 (NFJ54_01595) 342670..343500 + 831 WP_049035296.1 rhomboid family intramembrane serine protease GlpG -
NFJ54_RS01600 (NFJ54_01600) 343520..344278 + 759 WP_015369351.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13489.55 Da        Isoelectric Point: 7.2785

>T248289 WP_045394830.1 NZ_CP099260:339581-339928 [Klebsiella aerogenes]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKGSKFQNMKELRVQHHGLPVRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10782.55 Da        Isoelectric Point: 10.1464

>AT248289 WP_045394831.1 NZ_CP099260:339928-340227 [Klebsiella aerogenes]
MGTLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQISQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References