248285

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4703647..4704246 Replicon chromosome
Accession NZ_CP099254
Organism Citrobacter freundii strain RHB09-E3-C07

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFJ59_RS22115 Protein ID WP_100193804.1
Coordinates 4703935..4704246 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFJ59_RS22110 Protein ID WP_079939299.1
Coordinates 4703647..4703934 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ59_RS22095 (4701143) 4701143..4702045 + 903 WP_115259809.1 formate dehydrogenase O subunit beta -
NFJ59_RS22100 (4702042) 4702042..4702677 + 636 WP_096758858.1 formate dehydrogenase cytochrome b556 subunit -
NFJ59_RS22105 (4702674) 4702674..4703603 + 930 WP_096758859.1 formate dehydrogenase accessory protein FdhE -
NFJ59_RS22110 (4703647) 4703647..4703934 - 288 WP_079939299.1 NadS family protein Antitoxin
NFJ59_RS22115 (4703935) 4703935..4704246 - 312 WP_100193804.1 toxin HigB-2 Toxin
NFJ59_RS22120 (4704467) 4704467..4705381 + 915 WP_279277428.1 alpha/beta hydrolase -
NFJ59_RS22125 (4705420) 4705420..4706361 - 942 WP_181618151.1 fatty acid biosynthesis protein FabY -
NFJ59_RS22130 (4706406) 4706406..4706843 - 438 WP_181618152.1 D-aminoacyl-tRNA deacylase -
NFJ59_RS22135 (4706840) 4706840..4707712 - 873 WP_181618153.1 virulence factor BrkB family protein -
NFJ59_RS22140 (4707706) 4707706..4708305 - 600 WP_096758866.1 glucose-1-phosphatase -
NFJ59_RS22145 (4708411) 4708411..4709214 - 804 WP_279277429.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12261.38 Da        Isoelectric Point: 10.0972

>T248285 WP_100193804.1 NZ_CP099254:c4704246-4703935 [Citrobacter freundii]
MLFIETEIFTEDVKKLLDDDEYRRLQIFLTIQPDCGDLIQDTGGLRKVRWRARGKGKRGGVRIIYFHQIRKSQIRLLLIY
QKGIKDDLTPQEKVLLRMLNEGW

Download         Length: 312 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10775.39 Da        Isoelectric Point: 11.1842

>AT248285 WP_079939299.1 NZ_CP099254:c4703934-4703647 [Citrobacter freundii]
MDKALFERLTQSMIQMNEIAEGTRQPSRTFHIDAMKIKEIRQSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References