Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 362690..363356 Replicon chromosome
Accession NZ_CP099254
Organism Citrobacter freundii strain RHB09-E3-C07

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFJ59_RS01745 Protein ID WP_117342464.1
Coordinates 363039..363356 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag NFJ59_RS01740 Protein ID WP_003837894.1
Coordinates 362690..362986 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ59_RS01725 (359864) 359864..360337 - 474 WP_003023524.1 transcription elongation factor GreB -
NFJ59_RS01730 (360564) 360564..361283 + 720 WP_001157751.1 two-component system response regulator OmpR -
NFJ59_RS01735 (361280) 361280..362632 + 1353 WP_096759268.1 two-component system sensor histidine kinase EnvZ -
NFJ59_RS01740 (362690) 362690..362986 - 297 WP_003837894.1 NadS family protein Antitoxin
NFJ59_RS01745 (363039) 363039..363356 - 318 WP_117342464.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ59_RS01750 (363480) 363480..365102 - 1623 WP_182270802.1 phosphoenolpyruvate carboxykinase (ATP) -
NFJ59_RS01755 (365481) 365481..367199 + 1719 WP_182270803.1 DUF4153 domain-containing protein -
NFJ59_RS01760 (367250) 367250..368128 - 879 WP_181618419.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12226.13 Da        Isoelectric Point: 9.8310

>T248274 WP_117342464.1 NZ_CP099254:c363356-363039 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSDMLI

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT248274 WP_003837894.1 NZ_CP099254:c362986-362690 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References