Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 32633..33283 Replicon chromosome
Accession NZ_CP099254
Organism Citrobacter freundii strain RHB09-E3-C07

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFJ59_RS00165 Protein ID WP_279277480.1
Coordinates 32633..32974 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFJ59_RS00170 Protein ID WP_182270704.1
Coordinates 32984..33283 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ59_RS00145 (29032) 29032..30423 + 1392 WP_182270702.1 hexose-6-phosphate:phosphate antiporter -
NFJ59_RS00150 (30467) 30467..31372 - 906 WP_181618244.1 LysR family transcriptional regulator -
NFJ59_RS00155 (31478) 31478..31930 + 453 WP_182270703.1 DUF1198 family protein -
NFJ59_RS00160 (32030) 32030..32554 + 525 WP_181618246.1 SRPBCC domain-containing protein -
NFJ59_RS00165 (32633) 32633..32974 + 342 WP_279277480.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ59_RS00170 (32984) 32984..33283 + 300 WP_182270704.1 helix-turn-helix transcriptional regulator Antitoxin
NFJ59_RS00175 (33403) 33403..34596 + 1194 WP_181618249.1 purine ribonucleoside efflux pump NepI -
NFJ59_RS00180 (34704) 34704..36080 - 1377 WP_181618250.1 carbohydrate porin -
NFJ59_RS00185 (36288) 36288..36590 - 303 WP_008786514.1 PTS lactose/cellobiose transporter subunit IIA -
NFJ59_RS00190 (36603) 36603..37985 - 1383 WP_182270705.1 glycoside hydrolase family 1 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13045.87 Da        Isoelectric Point: 6.2275

>T248271 WP_279277480.1 NZ_CP099254:32633-32974 [Citrobacter freundii]
MWDVETTDAFDKWFDVQTEAFKEDMLAAMMILSEYGPQLGRPFADTVNDSAFSNMKELRVQHQGNPIRAFFAFDPSRHGI
VLCAGGKTGINEKKFYKDMIKFADVEYRKHLNK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10917.76 Da        Isoelectric Point: 8.6007

>AT248271 WP_182270704.1 NZ_CP099254:32984-33283 [Citrobacter freundii]
MATLKELMAKQSPESQERIAEKVEVLRQAVALSMLREELNLSQAELASVMGVKQPTIAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPTGKRVAFHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References