Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 359270..359936 Replicon chromosome
Accession NZ_CP099217
Organism Citrobacter freundii strain RHB16-SO-C03

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFJ87_RS01715 Protein ID WP_172750178.1
Coordinates 359619..359936 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag NFJ87_RS01710 Protein ID WP_003837894.1
Coordinates 359270..359566 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ87_RS01695 (356446) 356446..356919 - 474 WP_003023524.1 transcription elongation factor GreB -
NFJ87_RS01700 (357145) 357145..357864 + 720 WP_001157751.1 two-component system response regulator OmpR -
NFJ87_RS01705 (357861) 357861..359213 + 1353 WP_003837891.1 two-component system sensor histidine kinase EnvZ -
NFJ87_RS01710 (359270) 359270..359566 - 297 WP_003837894.1 NadS family protein Antitoxin
NFJ87_RS01715 (359619) 359619..359936 - 318 WP_172750178.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ87_RS01720 (360059) 360059..361681 - 1623 WP_003023529.1 phosphoenolpyruvate carboxykinase (ATP) -
NFJ87_RS01725 (362060) 362060..363778 + 1719 WP_279270539.1 DUF4153 domain-containing protein -
NFJ87_RS01730 (363888) 363888..364766 - 879 WP_003023531.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12238.14 Da        Isoelectric Point: 10.0909

>T248230 WP_172750178.1 NZ_CP099217:c359936-359619 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDNIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT248230 WP_003837894.1 NZ_CP099217:c359566-359270 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References