Detailed information of TA system TA024823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 3182093..3182945
• Replicon: chromosome
• Accession: NC_014306
• Organism: Erwinia billingiae Eb661

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: D8MU81
• Locus tag: EBC_RS16010
• Protein ID: WP_013202873.1
• Coordinates: 3182093..3182581 (-)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: EBC_RS16015
• Protein ID: WP_013202874.1
• Coordinates: 3182607..3182945 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBC_RS15985	3177214..3178311	+	1098	WP_013202868.1	NADH:flavin oxidoreductase	-
EBC_RS15990	3178508..3178993	+	486	WP_041692056.1	GNAT family N-acetyltransferase	-
EBC_RS15995	3179064..3180080	-	1017	WP_041692057.1	NADP-dependent oxidoreductase	-
EBC_RS16000	3180170..3181072	+	903	WP_013202871.1	LysR family transcriptional regulator	-
EBC_RS16005	3181184..3181924	-	741	WP_013202872.1	SDR family oxidoreductase	-
EBC_RS16010	3182093..3182581	-	489	WP_013202873.1	type II toxin-antitoxin system YhaV family toxin	Toxin
EBC_RS16015	3182607..3182945	-	339	WP_013202874.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
EBC_RS16020	3183096..3183743	-	648	WP_013202875.1	DUF1028 domain-containing protein	-
EBC_RS16025	3183865..3185451	+	1587	WP_013202876.1	ABC transporter substrate-binding protein	-
EBC_RS16030	3185472..3186419	+	948	WP_013202877.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-147)

Antitoxin

• PrlF antitoxin (13-111)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 19303.28 Da
• Isoelectric Point: 10.0648

>T24823 WP_013202873.1 NC_014306:c3182581-3182093 [Erwinia billingiae Eb661]
MEYLEINGWKFYFHSCFLTQLAELQNKVLALKKKDPQGYHKKKETKLLAAIEQIITRVIPANPLDSHFRQGNTLGQDYRH
WYRVKFLQQFRLFFRFSVPHRTIIIGWVNDFGMLRAYGSKTDAYRVFERMLKSGEPPDDWDALLKHCQTDARVINSDISR
KY

Nucleotide

• Length: 489 bp

>T24823 NC_014306:c3182581-3182093 [Erwinia billingiae Eb661]
ATGGAGTATTTGGAGATTAATGGATGGAAATTCTATTTTCATTCCTGTTTTCTGACGCAGCTGGCTGAACTTCAAAATAA
AGTCCTGGCGCTGAAAAAAAAGGATCCTCAGGGCTATCACAAAAAGAAAGAAACCAAGCTGCTGGCGGCGATTGAGCAAA
TCATTACTCGGGTGATCCCGGCCAATCCACTGGACAGCCACTTTCGGCAGGGCAATACCTTAGGCCAGGATTACCGGCAC
TGGTACCGCGTCAAATTCCTGCAGCAATTTCGGTTATTCTTCCGCTTCAGCGTGCCCCACAGAACCATCATTATTGGTTG
GGTAAATGATTTCGGCATGCTTCGCGCTTATGGTTCGAAAACAGATGCCTATAGGGTATTTGAACGGATGCTGAAGTCTG
GTGAACCCCCTGATGACTGGGATGCGCTGCTGAAGCATTGCCAAACCGATGCCAGGGTTATAAACAGCGATATTTCTCGG
AAATATTAA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12442.07 Da
• Isoelectric Point: 4.1276

>AT24823 WP_013202874.1 NC_014306:c3182945-3182607 [Erwinia billingiae Eb661]
MNVNMADVSLRAESRLTERSQTTIPAAIRDALQLKPGEFIEYALLPGGKVVMSRREEEAEDPVVPQFLAFLENDMMTNPH
HIHAVPVEFWAGIQQLTAGVEVDLDGPLTDDE

Nucleotide

• Length: 339 bp

>AT24823 NC_014306:c3182945-3182607 [Erwinia billingiae Eb661]
ATGAATGTAAACATGGCAGACGTGTCTTTGCGCGCGGAGTCCCGACTCACTGAGCGTAGCCAGACCACCATCCCCGCCGC
GATTCGCGATGCGCTGCAACTGAAGCCGGGAGAATTCATTGAATACGCTCTGCTGCCCGGCGGTAAAGTCGTTATGTCTA
GACGAGAAGAAGAAGCGGAAGATCCGGTGGTCCCGCAGTTTCTGGCTTTCCTCGAAAACGACATGATGACCAACCCGCAT
CATATCCATGCAGTGCCAGTAGAATTTTGGGCAGGGATCCAGCAACTGACTGCTGGCGTTGAAGTCGATTTAGACGGGCC
GCTGACTGACGATGAGTAG

Structures

Toxin

• AlphaFold DB: D8MU81