Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 726892..727667 Replicon chromosome
Accession NZ_CP099140
Organism Klebsiella pneumoniae strain RHB28-SO-C05

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1W1JAQ8
Locus tag NFK38_RS03605 Protein ID WP_009308645.1
Coordinates 727182..727667 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NFK38_RS03600 Protein ID WP_004150912.1
Coordinates 726892..727185 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK38_RS03580 (NFK38_03580) 722100..722702 - 603 WP_004174410.1 short chain dehydrogenase -
NFK38_RS03585 (NFK38_03585) 722800..723711 + 912 WP_004181308.1 LysR family transcriptional regulator -
NFK38_RS03590 (NFK38_03590) 723712..724860 - 1149 WP_040215095.1 PLP-dependent aspartate aminotransferase family protein -
NFK38_RS03595 (NFK38_03595) 724871..726247 - 1377 WP_074428894.1 cystathionine beta-synthase -
NFK38_RS03600 (NFK38_03600) 726892..727185 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NFK38_RS03605 (NFK38_03605) 727182..727667 + 486 WP_009308645.1 GNAT family N-acetyltransferase Toxin
NFK38_RS03610 (NFK38_03610) 728371..728964 + 594 WP_004188553.1 hypothetical protein -
NFK38_RS03615 (NFK38_03615) 729061..729277 + 217 Protein_709 transposase -
NFK38_RS03625 (NFK38_03625) 729955..730668 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 729061..729213 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17595.60 Da        Isoelectric Point: 8.5144

>T248216 WP_009308645.1 NZ_CP099140:727182-727667 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT248216 WP_004150912.1 NZ_CP099140:726892-727185 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W1JAQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References