248190

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2450798..2451360 Replicon chromosome
Accession NZ_CP099084
Organism Citrobacter freundii strain RHB43-C17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFK79_RS12010 Protein ID WP_096757033.1
Coordinates 2450798..2451076 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFK79_RS12015 Protein ID WP_096757032.1
Coordinates 2451076..2451360 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK79_RS11990 (2445907) 2445907..2446338 - 432 WP_096757037.1 OsmC family protein -
NFK79_RS11995 (2446567) 2446567..2446707 + 141 WP_096757036.1 stationary-phase-induced ribosome-associated protein -
NFK79_RS12000 (2446887) 2446887..2448584 + 1698 WP_096757035.1 malate dehydrogenase -
NFK79_RS12005 (2448895) 2448895..2450610 + 1716 WP_096757034.1 ABC-F family ATP-binding cassette domain-containing protein -
NFK79_RS12010 (2450798) 2450798..2451076 + 279 WP_096757033.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK79_RS12015 (2451076) 2451076..2451360 + 285 WP_096757032.1 HigA family addiction module antitoxin Antitoxin
NFK79_RS12020 (2451465) 2451465..2452121 - 657 WP_096757031.1 formate dehydrogenase-N subunit gamma -
NFK79_RS12025 (2452114) 2452114..2452998 - 885 WP_115258486.1 formate dehydrogenase N subunit beta -
NFK79_RS12030 (2453012) 2453012..2456059 - 3048 WP_181499416.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10601.05 Da        Isoelectric Point: 9.5320

>T248190 WP_096757033.1 NZ_CP099084:2450798-2451076 [Citrobacter freundii]
MIMNFRHKGLRDLFLQGRTSGVTAKHVRRLRHRLAVIDAASHVTDINMPGYKLHALTGDRDGVWSISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10327.05 Da        Isoelectric Point: 8.8094

>AT248190 WP_096757032.1 NZ_CP099084:2451076-2451360 [Citrobacter freundii]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNAWSLAEAQ
KSVDISRLRKLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References