Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 365677..366343 Replicon chromosome
Accession NZ_CP099084
Organism Citrobacter freundii strain RHB43-C17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFK79_RS01695 Protein ID WP_181498852.1
Coordinates 366026..366343 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag NFK79_RS01690 Protein ID WP_003837894.1
Coordinates 365677..365973 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK79_RS01675 (362853) 362853..363326 - 474 WP_003023524.1 transcription elongation factor GreB -
NFK79_RS01680 (363553) 363553..364272 + 720 WP_001157751.1 two-component system response regulator OmpR -
NFK79_RS01685 (364269) 364269..365621 + 1353 WP_096759268.1 two-component system sensor histidine kinase EnvZ -
NFK79_RS01690 (365677) 365677..365973 - 297 WP_003837894.1 NadS family protein Antitoxin
NFK79_RS01695 (366026) 366026..366343 - 318 WP_181498852.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK79_RS01700 (366467) 366467..368089 - 1623 WP_096759270.1 phosphoenolpyruvate carboxykinase (ATP) -
NFK79_RS01705 (368468) 368468..370186 + 1719 WP_096759271.1 DUF4153 domain-containing protein -
NFK79_RS01710 (370237) 370237..371115 - 879 WP_096759272.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12229.08 Da        Isoelectric Point: 8.4447

>T248184 WP_181498852.1 NZ_CP099084:c366343-366026 [Citrobacter freundii]
MFTFIELQGFSKRSPLLLPDDEFRAFQEALIENPEAGDTIAGTEGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSDMLI

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT248184 WP_003837894.1 NZ_CP099084:c365973-365677 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References