Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 335504..336170 Replicon chromosome
Accession NZ_CP099037
Organism Citrobacter freundii strain RHB44-SO-C05

Toxin (Protein)


Gene name higB Uniprot ID A0A8B5Q945
Locus tag NFL15_RS01550 Protein ID WP_003847996.1
Coordinates 335853..336170 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFL15_RS01545 Protein ID WP_049001470.1
Coordinates 335504..335800 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL15_RS01530 (332680) 332680..333153 - 474 WP_003023524.1 transcription elongation factor GreB -
NFL15_RS01535 (333379) 333379..334098 + 720 WP_001157751.1 two-component system response regulator OmpR -
NFL15_RS01540 (334095) 334095..335447 + 1353 WP_003837891.1 two-component system sensor histidine kinase EnvZ -
NFL15_RS01545 (335504) 335504..335800 - 297 WP_049001470.1 NadS family protein Antitoxin
NFL15_RS01550 (335853) 335853..336170 - 318 WP_003847996.1 hypothetical protein Toxin
NFL15_RS01555 (336293) 336293..337915 - 1623 WP_003023529.1 phosphoenolpyruvate carboxykinase (ATP) -
NFL15_RS01560 (338294) 338294..340012 + 1719 WP_061549613.1 DUF4153 domain-containing protein -
NFL15_RS01565 (340122) 340122..341000 - 879 WP_003023531.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12225.15 Da        Isoelectric Point: 10.0909

>T248173 WP_003847996.1 NZ_CP099037:c336170-335853 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11147.89 Da        Isoelectric Point: 7.2050

>AT248173 WP_049001470.1 NZ_CP099037:c335800-335504 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKSEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5Q945

Antitoxin

Source ID Structure

References