Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 38900..39548 Replicon chromosome
Accession NZ_CP099037
Organism Citrobacter freundii strain RHB44-SO-C05

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFL15_RS00180 Protein ID WP_049000674.1
Coordinates 38900..39262 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFL15_RS00185 Protein ID WP_049000676.1
Coordinates 39249..39548 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL15_RS00165 (35359) 35359..36687 + 1329 WP_003023927.1 MFS transporter -
NFL15_RS00170 (36830) 36830..38221 + 1392 WP_003023929.1 hexose-6-phosphate:phosphate antiporter -
NFL15_RS00175 (38347) 38347..38799 + 453 WP_003023933.1 DUF1198 family protein -
NFL15_RS00180 (38900) 38900..39262 + 363 WP_049000674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFL15_RS00185 (39249) 39249..39548 + 300 WP_049000676.1 helix-turn-helix transcriptional regulator Antitoxin
NFL15_RS00190 (39667) 39667..40860 + 1194 WP_003840662.1 purine ribonucleoside efflux pump NepI -
NFL15_RS00195 (40910) 40910..42292 - 1383 WP_139935879.1 glycoside hydrolase family 1 protein -
NFL15_RS00200 (42387) 42387..42680 - 294 WP_003840665.1 YicS family protein -
NFL15_RS00205 (42811) 42811..43227 + 417 WP_003023951.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-88)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13716.59 Da        Isoelectric Point: 5.6550

>T248172 WP_049000674.1 NZ_CP099037:38900-39262 [Citrobacter freundii]
MWEVETTDAFDKWFDVQTEALKEDMLAAMMILSEYGPQLGRPFADTVNASAFSNMKGLRVQHQGSPIRAFFAFDPSRHGI
VLCAGDKTGLNEKKFYKEMIRLADAEYRNHLISKENYGYP

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10990.81 Da        Isoelectric Point: 8.5047

>AT248172 WP_049000676.1 NZ_CP099037:39249-39548 [Citrobacter freundii]
MATLKELMAKQSAESQERITEKVEILRQAVALNMLREELNLSQAELASAMGVKQPTIAKMEQADNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFYL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References