Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2352213..2352784 Replicon chromosome
Accession NZ_CP098926
Organism Halomonas sp. MS1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NF683_RS10735 Protein ID WP_089039103.1
Coordinates 2352213..2352491 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NF683_RS10740 Protein ID WP_009722157.1
Coordinates 2352491..2352784 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF683_RS10705 (NF683_10700) 2347758..2348579 + 822 WP_232471376.1 GNAT family N-acetyltransferase -
NF683_RS10710 (NF683_10705) 2348826..2349359 + 534 WP_253919993.1 AAA family ATPase -
NF683_RS10715 (NF683_10710) 2349595..2349963 + 369 WP_275050937.1 GFA family protein -
NF683_RS10720 (NF683_10715) 2350197..2350838 + 642 WP_089039106.1 CatB-related O-acetyltransferase -
NF683_RS10725 (NF683_10720) 2350984..2351391 + 408 WP_089039105.1 hypothetical protein -
NF683_RS10730 (NF683_10725) 2351485..2352027 + 543 WP_253919995.1 DinB family protein -
NF683_RS10735 (NF683_10730) 2352213..2352491 + 279 WP_089039103.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NF683_RS10740 (NF683_10735) 2352491..2352784 + 294 WP_009722157.1 HigA family addiction module antitoxin Antitoxin
NF683_RS10745 (NF683_10740) 2352902..2353864 + 963 WP_253919996.1 ribonuclease Z -
NF683_RS10750 (NF683_10745) 2354001..2355197 - 1197 WP_253919997.1 homoserine O-acetyltransferase -
NF683_RS10755 (NF683_10750) 2355275..2356447 - 1173 WP_253919998.1 UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase -
NF683_RS10760 (NF683_10755) 2356563..2357411 + 849 WP_253919999.1 NAD-dependent protein deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10749.27 Da        Isoelectric Point: 10.0575

>T248169 WP_089039103.1 NZ_CP098926:2352213-2352491 [Halomonas sp. MS1]
MIKSFRHKGLKRFYASGSTSGIQADHAKKLRMQLAALDTAVSVEDMDIPGFRLHPLKGRDKARWSIWINGNWRMTFEFRD
GNAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10879.43 Da        Isoelectric Point: 4.7164

>AT248169 WP_009722157.1 NZ_CP098926:2352491-2352784 [Halomonas sp. MS1]
MTMHNPPHPGEFIREVYLEPFGISSRQLASNLGVSPSTLSRLLKGDSGISPEMSLRLSKVLGRTPESWLSMQDMYDLWMA
RSTINLDDLQPLDFEAA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References