248156

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2447822..2448344 Replicon chromosome
Accession NZ_CP098834
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain GD19PS1

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NFH28_RS12055 Protein ID WP_000221343.1
Coordinates 2448060..2448344 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NFH28_RS12050 Protein ID WP_000885424.1
Coordinates 2447822..2448070 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH28_RS12025 (2443038) 2443038..2444504 + 1467 WP_000987828.1 hypothetical protein -
NFH28_RS12030 (2445312) 2445312..2446026 + 715 Protein_2360 helix-turn-helix domain-containing protein -
NFH28_RS12035 (2446082) 2446082..2446990 - 909 WP_010989018.1 hypothetical protein -
NFH28_RS12040 (2447133) 2447133..2447465 - 333 WP_000253154.1 DUF1493 family protein -
NFH28_RS12045 (2447455) 2447455..2447670 - 216 WP_000206207.1 hypothetical protein -
NFH28_RS12050 (2447822) 2447822..2448070 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NFH28_RS12055 (2448060) 2448060..2448344 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFH28_RS12060 (2448515) 2448515..2448904 + 390 WP_000194089.1 RidA family protein -
NFH28_RS12065 (2448956) 2448956..2450035 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NFH28_RS12070 (2450228) 2450228..2450716 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NFH28_RS12075 (2450761) 2450761..2452269 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2443041..2455126 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T248156 WP_000221343.1 NZ_CP098834:2448060-2448344 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT248156 WP_000885424.1 NZ_CP098834:2447822-2448070 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References