248095

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 86342..86927 Replicon plasmid p1VB280821
Accession NZ_CP098796
Organism Acinetobacter baumannii strain VB280821

Toxin (Protein)


Gene name higB Uniprot ID N9CJF7
Locus tag NE424_RS19770 Protein ID WP_000897307.1
Coordinates 86607..86927 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NE424_RS19765 Protein ID WP_000369781.1
Coordinates 86342..86614 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE424_RS19750 (NE424_19750) 81856..83181 - 1326 WP_252172182.1 ISNCY family transposase -
NE424_RS19755 (NE424_19755) 83434..84318 - 885 WP_000155092.1 Mph(E) family macrolide 2'-phosphotransferase -
NE424_RS19760 (NE424_19760) 84374..85849 - 1476 WP_000052512.1 ABC-F type ribosomal protection protein Msr(E) -
NE424_RS19765 (NE424_19765) 86342..86614 - 273 WP_000369781.1 NadS family protein Antitoxin
NE424_RS19770 (NE424_19770) 86607..86927 - 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NE424_RS19775 (NE424_19775) 87067..87486 + 420 WP_001180106.1 SMI1/KNR4 family protein -
NE424_RS19780 (NE424_19780) 87586..88794 - 1209 WP_042090285.1 IS256 family transposase -
NE424_RS19785 (NE424_19785) 88894..89175 - 282 WP_000985609.1 putative addiction module antidote protein -
NE424_RS19790 (NE424_19790) 89176..89478 - 303 WP_000286964.1 type II toxin-antitoxin system RelE/ParE family toxin -
NE424_RS19795 (NE424_19795) 89771..90861 + 1091 WP_252172194.1 IS4-like element ISAba33 family transposase -
NE424_RS19800 (NE424_19800) 90858..91346 + 489 WP_252172183.1 hypothetical protein -
NE424_RS19805 (NE424_19805) 91615..91902 + 288 WP_000438825.1 BrnT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(3)-IId / aph(3'')-Ib / mph(E) / msr(E) / aph(3')-VIa / blaOXA-58 / sul1 / qacE / blaCARB-2 / blaNDM-1 - 1..141631 141631
- inside IScluster/Tn aac(3)-IId / aph(3'')-Ib / mph(E) / msr(E) / aph(3')-VIa / blaOXA-58 / sul1 / qacE / blaCARB-2 - 72780..106272 33492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12187.95 Da        Isoelectric Point: 7.1639

>T248095 WP_000897307.1 NZ_CP098796:c86927-86607 [Acinetobacter baumannii]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG

Download         Length: 321 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10149.61 Da        Isoelectric Point: 8.6582

>AT248095 WP_000369781.1 NZ_CP098796:c86614-86342 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8TMZ3

Antitoxin

Source ID Structure

References