Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3459402..3460077 Replicon chromosome
Accession NZ_CP098778
Organism Enterobacter hormaechei strain YQ13422hy

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag ND013_RS16490 Protein ID WP_015571638.1
Coordinates 3459402..3459701 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag ND013_RS16495 Protein ID WP_015571639.1
Coordinates 3459712..3460077 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND013_RS16480 3455779..3457971 + 2193 WP_126498824.1 type I secretion system permease/ATPase -
ND013_RS16485 3457952..3459151 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
ND013_RS16490 3459402..3459701 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND013_RS16495 3459712..3460077 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
ND013_RS16500 3460104..3461285 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
ND013_RS16505 3461306..3462193 - 888 WP_015571641.1 LysR family transcriptional regulator -
ND013_RS16510 3462291..3462893 + 603 WP_017382759.1 short chain dehydrogenase -
ND013_RS16515 3463004..3464383 - 1380 WP_126498823.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T248085 WP_015571638.1 NZ_CP098778:3459402-3459701 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT248085 WP_015571639.1 NZ_CP098778:3459712-3460077 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References