Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1185280..1185829 Replicon chromosome
Accession NZ_CP098778
Organism Enterobacter hormaechei strain YQ13422hy

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ND013_RS05660 Protein ID WP_023296064.1
Coordinates 1185280..1185561 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0D7L8S0
Locus tag ND013_RS05665 Protein ID WP_015571209.1
Coordinates 1185542..1185829 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND013_RS05640 1180395..1181366 + 972 WP_045344575.1 LacI family DNA-binding transcriptional regulator -
ND013_RS05645 1181367..1182611 - 1245 WP_015571212.1 mechanosensitive ion channel family protein -
ND013_RS05650 1182679..1184115 - 1437 WP_017382555.1 MFS transporter -
ND013_RS05655 1184223..1185092 + 870 WP_045357441.1 helix-turn-helix transcriptional regulator -
ND013_RS05660 1185280..1185561 + 282 WP_023296064.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND013_RS05665 1185542..1185829 + 288 WP_015571209.1 helix-turn-helix transcriptional regulator Antitoxin
ND013_RS05670 1185866..1186519 - 654 WP_003858884.1 oxygen-insensitive NAD(P)H nitroreductase -
ND013_RS05675 1186640..1187008 - 369 WP_126499141.1 MmcQ/YjbR family DNA-binding protein -
ND013_RS05680 1186998..1187588 - 591 WP_003858882.1 TetR/AcrR family transcriptional regulator -
ND013_RS05685 1187780..1188883 + 1104 WP_126499142.1 RomA family MBL fold metallo-hydrolase -
ND013_RS05690 1188916..1189257 + 342 WP_003858880.1 RamA family antibiotic efflux transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-83)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-87)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10931.84 Da        Isoelectric Point: 10.8507

>T248077 WP_023296064.1 NZ_CP098778:1185280-1185561 [Enterobacter hormaechei]
MPAGVQAKLIRQLDKLRNNPTVLREPDSKPLPNGLFEIRTVGLIHTRGIYVYQRERTIFLLRVFIKKTQKTPSAELRLAL
KRQQEMLDEQKDY

Download         Length: 282 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10861.41 Da        Isoelectric Point: 7.1670

>AT248077 WP_015571209.1 NZ_CP098778:1185542-1185829 [Enterobacter hormaechei]
MSKKIIDWDELRAELLSDSEVQASFDAEERKERLREMLAQWRNHAGLTRAQVAERMGVSAPTVSRMEANITRASLDTLTR
YALVCGVKHPQITLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7L8S0

References