Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2831192..2831839 Replicon chromosome
Accession NZ_CP098777
Organism Cronobacter sakazakii strain JXES-28

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NES82_RS13870 Protein ID WP_161574444.1
Coordinates 2831492..2831839 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID V5TYW5
Locus tag NES82_RS13865 Protein ID WP_007776551.1
Coordinates 2831192..2831491 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NES82_RS13835 (NES82_13840) 2826602..2827168 + 567 WP_054624204.1 DedA family protein -
NES82_RS13840 (NES82_13845) 2827165..2827938 - 774 WP_054624203.1 SDR family oxidoreductase -
NES82_RS13845 (NES82_13850) 2828111..2828194 + 84 WP_000691708.1 small membrane protein YohP -
NES82_RS13850 (NES82_13855) 2828231..2829190 - 960 WP_161574443.1 MBL fold metallo-hydrolase -
NES82_RS13855 (NES82_13860) 2829263..2830186 + 924 WP_054624201.1 LysR family transcriptional regulator -
NES82_RS13860 (NES82_13865) 2830189..2831121 - 933 WP_032988286.1 tRNA dihydrouridine(16) synthase DusC -
NES82_RS13865 (NES82_13870) 2831192..2831491 - 300 WP_007776551.1 XRE family transcriptional regulator Antitoxin
NES82_RS13870 (NES82_13875) 2831492..2831839 - 348 WP_161574444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NES82_RS13875 (NES82_13880) 2832092..2832493 + 402 WP_007869367.1 CidA/LrgA family protein -
NES82_RS13880 (NES82_13885) 2832490..2833185 + 696 WP_063264311.1 CidB/LrgB family autolysis modulator -
NES82_RS13885 (NES82_13890) 2833315..2834199 + 885 WP_161574445.1 cytidine deaminase -
NES82_RS13890 (NES82_13895) 2834324..2835037 + 714 WP_007794951.1 outer membrane permeability protein SanA -
NES82_RS13895 (NES82_13900) 2835702..2836712 - 1011 WP_004387466.1 galactose/methyl galactoside ABC transporter permease MglC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13283.50 Da        Isoelectric Point: 10.0481

>T248068 WP_161574444.1 NZ_CP098777:c2831839-2831492 [Cronobacter sakazakii]
MWTIYLTHEFECWLAGQPQPLQEDVLAALGLLKIKGPHLGRPYADTLKGSRHAGMKALRVQHAGRPIRAFYAFDPHRYAI
VLCAAEKKGDEKRFYRVILRVADKLFSHYLNHREV

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11035.67 Da        Isoelectric Point: 5.1667

>AT248068 WP_007776551.1 NZ_CP098777:c2831491-2831192 [Cronobacter sakazakii]
MKTFDEVLAAQTPEARARIEEKTAQLLLETHLYALREALSVSQTEMARQMGIAQPSVAAIEQRGNEMKISTLKRYVEALG
GTVRLDVELPDGQRFGFTL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9UA72

References